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Publication that may very well be understood as further evidence of human exceptionalism.

Abstract: NOVA1, a neuronal RNA-binding protein expressed in the central nervous system, is essential for survival in mice and normal development in humans. A single amino acid change (I197V) in NOVA1’s second RNA binding domain is unique to modern humans. To study its physiological effects, we generated mice carrying the human-specific I197V variant (Nova1hu/hu) and analyzed the molecular and behavioral consequences. While the I197V substitution had minimal impact on NOVA1’s RNA binding capacity, it led to specific effects on alternative splicing, and CLIP revealed multiple binding peaks in mouse brain transcripts involved in vocalization. These molecular findings were associated with behavioral differences in vocalization patterns in Nova1hu/hu mice as pups and adults. Our findings suggest that this human-specific NOVA1 substitution may have been part of an ancient evolutionary selective sweep in a common ancestral population of Homo sapiens, possibly contributing to the development of spoken language through differential RNA regulation during brain development.

In this episode, biochemist Fuz Rana describes recent work from researchers at Rockefeller University. The researchers edited specific mouse genes to express the human version of the protein NOVA1, and they believe their research explains human language capability. Their findings add evidence for the exceptional nature of human beings and, consequently, the image of God.

Hugh discusses how four astrobiologists assert that intelligent life is the natural outcome of a hospitable environment. They note that the origin of life and every advance in Earth’s life occurred when physical and chemical conditions first permitted their appearance. Hence, they conclude that these appearances of life must be naturalistically straightforward and rapid. The team proposed a test of their hypothesis: exoplanets with the necessary physical and chemical conditions for each “hard step” in the origin and history of life will prove to be common and, in each case, chemical signatures for that life step will be found. Do the findings support their hypothesis?